This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ALKBH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALKBH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALKBH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:77,456,961–77,458,831 | 250.3 kb | Distal (>10kb) Multiome | 878 | |
| chr14:77,498,012–77,499,509 | 209.1 kb | Distal (>10kb) Multiome | 599 | |
| chr14:77,615,862–77,617,380 | 91.2 kb | Distal (>10kb) Multiome | 892 | |
| chr14:77,654,873–77,655,664 | 52.8 kb | Distal (>10kb) Multiome | 287 | |
| chr14:77,707,585–77,708,371 | 35 bp | At TSS Multiome | 744 | |
| chr14:77,760,384–77,761,929 | 53.1 kb | Distal (>10kb) Multiome | 755 | |
| chr14:77,799,937–77,800,798 | 92.2 kb | Distal (>10kb) Multiome | 865 | |
| chr14:77,965,921–77,966,514 | 258.2 kb | Distal (>10kb) Multiome | 258 | |
| chr14:77,980,545–77,981,614 | 273.1 kb | Distal (>10kb) Multiome | 329 |
Genomic view of the ALKBH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.