This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for ALG5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALG5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALG5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:36,761,910–36,762,570 | 237.2 kb | Distal (>10kb) Multiome | 247 | |
| chr13:36,818,153–36,820,403 | 180.2 kb | Distal (>10kb) Multiome | 690 | |
| chr13:36,919,257–36,920,884 | 79.2 kb | Distal (>10kb) Multiome | 481 | |
| chr13:36,998,372–37,001,433 | 20 bp | At TSS Multiome | 1090 | |
| chr13:37,058,947–37,060,264 | 60.4 kb | Distal (>10kb) Multiome | 801 |
Genomic view of the ALG5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.