This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]
Transcription factors with Perturb-seq knockdown data for ALDOA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALDOA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALDOA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,784,957–29,785,426 | 278.9 kb | Distal (>10kb) Multiome | 452 | |
| chr16:29,790,073–29,791,192 | 273.5 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:29,804,592–29,808,172 | 258.4 kb | Distal (>10kb) Multiome | 1275 | |
| chr16:29,810,746–29,812,649 | 251.8 kb | Distal (>10kb) Multiome | 826 | |
| chr16:29,815,828–29,817,186 | 248.0 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:29,862,597–29,863,901 | 200.7 kb | Distal (>10kb) Multiome | 953 | |
| chr16:29,876,281–29,878,282 | 186.5 kb | Distal (>10kb) Multiome | 319 | |
| chr16:29,899,174–29,900,833 | 164.7 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 137.9 kb | Distal (>10kb) Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 102.2 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 90.5 kb | Distal (>10kb) Multiome | 935 | |
| chr16:29,994,888–29,996,728 | 68.0 kb | Distal (>10kb) Multiome | 1080 | |
| chr16:30,021,215–30,021,860 | 42.6 kb | Distal (>10kb) Multiome | 764 | |
| chr16:30,052,803–30,053,364 | 11.1 kb | Distal (>10kb) Multiome | 989 | |
| chr16:30,055,113–30,055,305 | 8.9 kb | Proximal (<10kb) | 344 | |
| chr16:30,063,722–30,066,296 | 76 bp | At TSS Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 11.8 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 28.7 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 32.2 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,122,728–30,123,578 | 59.1 kb | Distal (>10kb) Multiome | 718 | |
| chr16:30,182,759–30,183,865 | 119.3 kb | Distal (>10kb) Multiome | 547 | |
| chr16:30,334,526–30,335,777 | 271.2 kb | Distal (>10kb) Multiome | 486 | |
| chr16:30,354,854–30,355,978 | 291.2 kb | Distal (>10kb) Multiome | 1070 |
Genomic view of the ALDOA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.