This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for ALDH1L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALDH1L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALDH1L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:103,956,327–103,957,900 | 1150.3 kb | Distal (>10kb) Multiome HiCAR | 1090 | |
| chr12:104,215,473–104,216,381 | 891.7 kb | Distal (>10kb) Multiome HiCAR | 514 | |
| chr12:104,286,560–104,287,505 | 820.7 kb | Distal (>10kb) Multiome HiCAR | 878 | |
| chr12:104,288,643–104,289,175 | 818.8 kb | Distal (>10kb) Multiome HiCAR | 863 | |
| chr12:104,957,697–104,958,992 | 149.4 kb | Distal (>10kb) Multiome | 811 | |
| chr12:104,986,118–104,986,938 | 121.3 kb | Distal (>10kb) Multiome | 665 | |
| chr12:105,083,642–105,085,161 | 23.1 kb | Distal (>10kb) Multiome | 490 | |
| chr12:105,107,164–105,108,312 | 92 bp | At TSS Multiome | 1033 | |
| chr12:105,235,605–105,236,419 | 128.5 kb | Distal (>10kb) Multiome | 802 | |
| chr12:105,330,237–105,331,332 | 223.0 kb | Distal (>10kb) Multiome | 497 |
Genomic view of the ALDH1L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.