This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]
Transcription factors with Perturb-seq knockdown data for AKT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:39,996,681–39,997,502 | 288.3 kb | Distal (>10kb) Multiome | 898 | |
| chr19:40,055,898–40,056,369 | 229.2 kb | Distal (>10kb) Multiome | 746 | |
| chr19:40,090,491–40,091,099 | 194.5 kb | Distal (>10kb) Multiome | 831 | |
| chr19:40,190,883–40,192,408 | 93.5 kb | Distal (>10kb) Multiome | 764 | |
| chr19:40,217,060–40,217,642 | 68.1 kb | Distal (>10kb) Multiome | 366 | |
| chr19:40,284,527–40,285,917 | 29 bp | At TSS Multiome | 913 | |
| chr19:40,347,917–40,348,964 | 63.2 kb | Distal (>10kb) Multiome | 843 | |
| chr19:40,365,649–40,366,111 | 80.5 kb | Distal (>10kb) Multiome | 244 | |
| chr19:40,398,541–40,399,285 | 113.6 kb | Distal (>10kb) Multiome | 234 | |
| chr19:40,403,323–40,404,681 | 118.3 kb | Distal (>10kb) Multiome | 638 | |
| chr19:40,420,702–40,421,699 | 135.8 kb | Distal (>10kb) Multiome | 966 | |
| chr19:40,424,783–40,426,631 | 140.6 kb | Distal (>10kb) Multiome | 954 | |
| chr19:40,433,505–40,434,546 | 148.7 kb | Distal (>10kb) Multiome | 791 | |
| chr19:40,442,698–40,445,144 | 157.9 kb | Distal (>10kb) Multiome | 994 | |
| chr19:40,465,326–40,466,635 | 180.6 kb | Distal (>10kb) Multiome | 815 | |
| chr19:40,487,850–40,488,306 | 202.8 kb | Distal (>10kb) Multiome | 193 | |
| chr19:40,519,457–40,519,993 | 234.3 kb | Distal (>10kb) Multiome | 222 | |
| chr19:40,528,978–40,529,879 | 244.0 kb | Distal (>10kb) Multiome | 601 | |
| chr19:40,529,987–40,530,863 | 245.3 kb | Distal (>10kb) Multiome | 384 | |
| chr19:40,549,036–40,549,555 | 264.0 kb | Distal (>10kb) Multiome | 372 | |
| chr19:40,570,181–40,571,253 | 285.4 kb | Distal (>10kb) Multiome | 598 | |
| chr19:40,576,133–40,577,495 | 291.5 kb | Distal (>10kb) Multiome | 616 |
Genomic view of the AKT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.