AKT1S1

AKT1 substrate 1 | Lobe, MGC2865, PRAS40

AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]

Developmental clusters: GC1

Biological processes 21 terms

TORC1 complex (GO:0031931)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)negative regulation of TOR signaling (GO:0032007)negative regulation of TOR signaling (GO:0032007)negative regulation of TORC1 signaling (GO:1904262)negative regulation of TORC1 signaling (GO:1904262)negative regulation of cell size (GO:0045792)negative regulation of protein kinase activity (GO:0006469)neurotrophin TRK receptor signaling pathway (GO:0048011)nucleoplasm (GO:0005654)protein binding (GO:0005515)protein kinase inhibitor activity (GO:0004860)protein serine/threonine kinase inhibitor activity (GO:0030291)regulation of apoptotic process (GO:0042981)regulation of apoptotic process (GO:0042981)regulation of neuron apoptotic process (GO:0043523)regulation of neuron apoptotic process (GO:0043523)

Expression (TPM)

TFs regulating AKT1S1 0 TFs

Transcription factors with Perturb-seq knockdown data for AKT1S1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKT1S1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to AKT1S1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKT1S1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:49,580,125–49,580,813	296.7 kb	Distal (>10kb) Multiome	848
chr19:49,589,601–49,594,008	283.7 kb	Distal (>10kb) Multiome	994
chr19:49,638,063–49,638,728	239.0 kb	Distal (>10kb) Multiome	237
chr19:49,639,671–49,642,787	236.9 kb	Distal (>10kb) Multiome	1067
chr19:49,664,165–49,665,096	212.8 kb	Distal (>10kb) Multiome	679
chr19:49,665,345–49,666,430	211.4 kb	Distal (>10kb) Multiome	721
chr19:49,672,105–49,672,787	204.9 kb	Distal (>10kb) Multiome	625
chr19:49,676,058–49,678,754	200.3 kb	Distal (>10kb) Multiome	1033
chr19:49,680,433–49,681,147	196.5 kb	Distal (>10kb) Multiome	435
chr19:49,690,485–49,691,761	186.2 kb	Distal (>10kb) Multiome	327
chr19:49,746,188–49,746,748	130.8 kb	Distal (>10kb) Multiome	283
chr19:49,766,231–49,767,440	110.6 kb	Distal (>10kb) Multiome	718
chr19:49,802,146–49,802,787	74.8 kb	Distal (>10kb) Multiome	200
chr19:49,805,226–49,805,871	71.7 kb	Distal (>10kb) Multiome	245
chr19:49,808,201–49,809,746	68.3 kb	Distal (>10kb) Multiome	509
chr19:49,812,926–49,813,834	63.8 kb	Distal (>10kb) Multiome	650
chr19:49,817,356–49,818,721	59.1 kb	Distal (>10kb) Multiome	784
chr19:49,850,394–49,852,067	26.4 kb	Distal (>10kb) Multiome	862
chr19:49,866,817–49,868,124	9.9 kb	Proximal (<10kb) Multiome	874
chr19:49,869,068–49,870,398	7.6 kb	Proximal (<10kb) Multiome	832
chr19:49,875,842–49,878,576	473 bp	At TSS Multiome	1153
chr19:49,889,853–49,891,381	13.2 kb	Distal (>10kb) Multiome	640
chr19:49,928,884–49,930,473	52.6 kb	Distal (>10kb) Multiome	1141
chr19:49,987,157–49,987,669	110.1 kb	Distal (>10kb) Multiome	1095
chr19:50,024,875–50,026,285	148.4 kb	Distal (>10kb) Multiome	1137
chr19:50,147,523–50,148,432	270.8 kb	Distal (>10kb) Multiome	615

Genome Browser

Genomic view of the AKT1S1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.