This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for AKR1B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKR1B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKR1B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:132,475,108–132,476,093 | 1983.3 kb | Distal (>10kb) Multiome HiCAR | 120 | |
| chr7:134,316,231–134,317,622 | 142.1 kb | Distal (>10kb) Multiome | 905 | |
| chr7:134,432,345–134,433,248 | 26.4 kb | Distal (>10kb) Multiome | 622 | |
| chr7:134,457,695–134,457,969 | 1.1 kb | Proximal (<10kb) | 21 | |
| chr7:134,458,208–134,459,715 | 10 bp | At TSS Multiome | 797 | |
| chr7:134,547,422–134,548,048 | 88.5 kb | Distal (>10kb) Multiome | 442 | |
| chr7:134,646,328–134,647,406 | 187.7 kb | Distal (>10kb) Multiome | 748 |
Genomic view of the AKR1B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.