This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for AKR1A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKR1A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKR1A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:44,775,008–44,776,007 | 775.3 kb | Distal (>10kb) Multiome HiCAR | 1041 | |
| chr1:45,303,203–45,304,881 | 247.0 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:45,315,837–45,316,870 | 234.7 kb | Distal (>10kb) Multiome | 113 | |
| chr1:45,317,165–45,317,643 | 233.4 kb | Distal (>10kb) Multiome | 7 | |
| chr1:45,321,623–45,322,180 | 229.1 kb | Distal (>10kb) Multiome | 54 | |
| chr1:45,326,327–45,328,092 | 224.0 kb | Distal (>10kb) Multiome | 382 | |
| chr1:45,339,505–45,340,694 | 210.7 kb | Distal (>10kb) Multiome | 951 | |
| chr1:45,490,605–45,491,773 | 59.5 kb | Distal (>10kb) Multiome | 900 | |
| chr1:45,499,499–45,500,620 | 50.7 kb | Distal (>10kb) Multiome | 831 | |
| chr1:45,521,163–45,522,604 | 28.9 kb | Distal (>10kb) Multiome | 1155 | |
| chr1:45,550,427–45,551,304 | 13 bp | At TSS Multiome | 1006 | |
| chr1:45,583,145–45,585,182 | 33.9 kb | Distal (>10kb) Multiome | 997 | |
| chr1:45,622,461–45,623,374 | 72.2 kb | Distal (>10kb) Multiome | 169 | |
| chr1:45,686,052–45,687,740 | 136.3 kb | Distal (>10kb) Multiome | 1015 | |
| chr1:45,687,860–45,688,505 | 137.6 kb | Distal (>10kb) Multiome | 861 | |
| chr1:45,750,186–45,751,093 | 199.9 kb | Distal (>10kb) Multiome | 961 | |
| chr1:45,802,824–45,804,412 | 252.8 kb | Distal (>10kb) Multiome | 753 |
Genomic view of the AKR1A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.