Predicted to enable DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in centrosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AKNA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKNA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKNA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:114,097,958–114,099,449 | 289.4 kb | Distal (>10kb) Multiome | 455 | |
| chr9:114,107,965–114,108,461 | 279.8 kb | Distal (>10kb) Multiome | 481 | |
| chr9:114,153,818–114,154,827 | 233.9 kb | Distal (>10kb) Multiome | 561 | |
| chr9:114,154,931–114,156,548 | 232.5 kb | Distal (>10kb) Multiome | 513 | |
| chr9:114,370,337–114,371,120 | 17.4 kb | Distal (>10kb) Multiome HiCAR | 151 | |
| chr9:114,383,028–114,383,485 | 4.5 kb | Proximal (<10kb) | 151 | |
| chr9:114,387,530–114,388,416 | 53 bp | At TSS Multiome | 315 | |
| chr9:114,392,159–114,392,493 | 4.2 kb | Proximal (<10kb) | 66 | |
| chr9:114,396,942–114,397,190 | 9.0 kb | Proximal (<10kb) | 248 | |
| chr9:114,397,621–114,398,973 | 10.4 kb | Distal (>10kb) Multiome HiCAR | 744 | |
| chr9:114,504,150–114,506,064 | 117.6 kb | Distal (>10kb) Multiome | 672 | |
| chr9:114,583,376–114,584,037 | 195.7 kb | Distal (>10kb) Multiome | 117 | |
| chr9:114,587,169–114,588,239 | 199.7 kb | Distal (>10kb) Multiome | 922 | |
| chr9:114,610,961–114,612,019 | 223.5 kb | Distal (>10kb) Multiome | 923 |
Genomic view of the AKNA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.