AKAP8L
A-kinase anchoring protein 8 like | HAP95, NAKAP95

Enables histone deacetylase binding activity and lamin binding activity. Involved in several processes, including cell cycle G2/M phase transition; mitotic chromosome condensation; and regulation of mRNA export from nucleus. Located in chromatin; cytoplasm; and nuclear lumen. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2
Biological processes 30 terms
DEAD/H-box RNA helicase binding (GO:0017151)DNA binding (GO:0003677)PML body (GO:0016605)RNA binding (GO:0003723)cell cycle G2/M phase transition (GO:0044839)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoplasm (GO:0005737)histone deacetylase binding (GO:0042826)lamin binding (GO:0005521)mRNA processing (GO:0006397)mitotic chromosome condensation (GO:0007076)mitotic chromosome condensation (GO:0007076)nuclear lumen (GO:0031981)nuclear matrix (GO:0016363)nuclear matrix (GO:0016363)nuclear matrix (GO:0016363)nuclear membrane disassembly (GO:0051081)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein kinase A regulatory subunit binding (GO:0034237)regulation of mRNA export from nucleus (GO:0010793)ribonucleoprotein complex (GO:1990904)
Expression (TPM)
AKAP8L — as a Regulated Gene

TFs regulating AKAP8L 0 TFs

Transcription factors with Perturb-seq knockdown data for AKAP8L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKAP8L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to AKAP8L

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKAP8L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:14,556,545–14,557,088 862.2 kb Distal (>10kb) Multiome HiCAR 509
chr19:15,124,546–15,126,107 293.3 kb Distal (>10kb) Multiome 949
chr19:15,177,520–15,178,026 241.3 kb Distal (>10kb) Multiome 499
chr19:15,180,886–15,181,623 237.7 kb Distal (>10kb) Multiome 355
chr19:15,195,187–15,196,375 222.9 kb Distal (>10kb) Multiome 408
chr19:15,199,629–15,201,437 218.9 kb Distal (>10kb) Multiome 398
chr19:15,222,727–15,224,168 195.5 kb Distal (>10kb) Multiome 521
chr19:15,231,632–15,233,858 185.8 kb Distal (>10kb) Multiome 414
chr19:15,324,741–15,325,392 94.0 kb Distal (>10kb) Multiome 183
chr19:15,331,471–15,332,992 86.5 kb Distal (>10kb) Multiome 641
chr19:15,378,833–15,380,802 39.1 kb Distal (>10kb) Multiome 913
chr19:15,412,942–15,413,236 5.8 kb Proximal (<10kb) 53
chr19:15,418,493–15,419,441 167 bp At TSS Multiome 892
chr19:15,432,448–15,433,787 13.9 kb Distal (>10kb) Multiome 766
chr19:15,449,146–15,450,281 30.9 kb Distal (>10kb) Multiome 446
chr19:15,451,962–15,453,427 33.5 kb Distal (>10kb) Multiome 428
chr19:15,456,680–15,457,763 38.2 kb Distal (>10kb) Multiome 240
chr19:15,555,803–15,556,689 137.1 kb Distal (>10kb) Multiome 669
chr19:16,075,837–16,077,586 657.4 kb Distal (>10kb) Multiome HiCAR 735
chr19:16,184,971–16,186,029 766.4 kb Distal (>10kb) Multiome HiCAR 658

Genome Browser

Genomic view of the AKAP8L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:14,546,545 – 16,196,029
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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