This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for AKAP10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKAP10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKAP10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:19,744,539–19,745,417 | 232.8 kb | Distal (>10kb) Multiome | 325 | |
| chr17:19,866,833–19,868,282 | 110.0 kb | Distal (>10kb) Multiome | 560 | |
| chr17:19,977,322–19,978,428 | 54 bp | At TSS Multiome | 1017 | |
| chr17:19,992,824–19,993,272 | 15.2 kb | Distal (>10kb) Multiome | 455 | |
| chr17:20,008,666–20,010,100 | 31.5 kb | Distal (>10kb) Multiome | 646 | |
| chr17:20,155,600–20,156,828 | 178.2 kb | Distal (>10kb) Multiome | 631 |
Genomic view of the AKAP10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.