This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for AK6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AK6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AK6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:69,093,377–69,094,772 | 275.6 kb | Distal (>10kb) Multiome | 952 | |
| chr5:69,166,575–69,167,819 | 202.5 kb | Distal (>10kb) Multiome | 840 | |
| chr5:69,188,979–69,190,115 | 179.9 kb | Distal (>10kb) Multiome | 898 | |
| chr5:69,217,542–69,218,587 | 151.5 kb | Distal (>10kb) Multiome | 898 | |
| chr5:69,234,302–69,235,305 | 134.7 kb | Distal (>10kb) Multiome | 732 | |
| chr5:69,300,544–69,301,286 | 68.7 kb | Distal (>10kb) Multiome | 217 | |
| chr5:69,368,998–69,370,235 | 157 bp | At TSS Multiome | 956 | |
| chr5:69,414,852–69,415,897 | 45.6 kb | Distal (>10kb) Multiome | 714 | |
| chr5:69,492,169–69,494,057 | 123.2 kb | Distal (>10kb) Multiome | 821 | |
| chr5:69,499,604–69,500,518 | 130.6 kb | Distal (>10kb) Multiome | 300 |
Genomic view of the AK6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.