The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for AIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,239,493–67,240,241 | 243.1 kb | Distal (>10kb) Multiome | 792 | |
| chr11:67,265,898–67,267,077 | 216.6 kb | Distal (>10kb) Multiome | 471 | |
| chr11:67,288,260–67,289,971 | 193.9 kb | Distal (>10kb) Multiome | 985 | |
| chr11:67,302,488–67,304,170 | 179.6 kb | Distal (>10kb) Multiome | 661 | |
| chr11:67,316,992–67,318,501 | 165.3 kb | Distal (>10kb) Multiome | 918 | |
| chr11:67,352,967–67,354,228 | 129.4 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,372,171–67,373,596 | 110.0 kb | Distal (>10kb) Multiome | 497 | |
| chr11:67,391,276–67,392,428 | 91.1 kb | Distal (>10kb) Multiome | 957 | |
| chr11:67,401,038–67,402,351 | 81.1 kb | Distal (>10kb) Multiome | 741 | |
| chr11:67,420,418–67,421,666 | 61.8 kb | Distal (>10kb) Multiome | 648 | |
| chr11:67,428,036–67,428,950 | 54.6 kb | Distal (>10kb) Multiome | 813 | |
| chr11:67,443,182–67,444,063 | 39.4 kb | Distal (>10kb) Multiome | 612 | |
| chr11:67,464,410–67,465,252 | 18.3 kb | Distal (>10kb) Multiome | 710 | |
| chr11:67,468,551–67,469,666 | 13.7 kb | Distal (>10kb) Multiome | 774 | |
| chr11:67,482,830–67,483,745 | 126 bp | At TSS Multiome | 969 | |
| chr11:67,504,073–67,506,408 | 23.3 kb | Distal (>10kb) Multiome | 769 | |
| chr11:67,507,504–67,509,030 | 25.3 kb | Distal (>10kb) Multiome | 897 | |
| chr11:67,583,474–67,584,777 | 100.7 kb | Distal (>10kb) Multiome | 633 | |
| chr11:67,606,302–67,607,213 | 123.8 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,614,064–67,614,626 | 131.2 kb | Distal (>10kb) Multiome | 383 | |
| chr11:67,619,429–67,620,391 | 136.8 kb | Distal (>10kb) Multiome | 50 | |
| chr11:67,628,876–67,631,242 | 147.4 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:67,757,971–67,758,804 | 275.3 kb | Distal (>10kb) Multiome | 61 |
Genomic view of the AIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.