This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for AIFM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AIFM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AIFM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:69,876,839–69,877,624 | 255.6 kb | Distal (>10kb) Multiome | 45 | |
| chr10:70,052,471–70,054,619 | 80.1 kb | Distal (>10kb) Multiome | 577 | |
| chr10:70,075,065–70,075,566 | 57.6 kb | Distal (>10kb) Multiome | 23 | |
| chr10:70,116,082–70,116,892 | 16.4 kb | Distal (>10kb) Multiome | 217 | |
| chr10:70,132,124–70,133,061 | 94 bp | At TSS Multiome | 729 | |
| chr10:70,142,275–70,142,773 | 9.4 kb | Proximal (<10kb) | 9 | |
| chr10:70,145,328–70,147,235 | 12.8 kb | Distal (>10kb) Multiome | 1006 | |
| chr10:70,169,902–70,171,034 | 37.8 kb | Distal (>10kb) Multiome | 777 | |
| chr10:70,232,204–70,234,260 | 100.8 kb | Distal (>10kb) Multiome | 949 | |
| chr10:70,381,835–70,383,091 | 249.9 kb | Distal (>10kb) Multiome | 693 | |
| chr10:70,403,687–70,404,709 | 271.3 kb | Distal (>10kb) Multiome | 788 |
Genomic view of the AIFM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.