Enables actin filament binding activity. Predicted to be involved in actin filament bundle assembly and ruffle assembly. Located in actin filament and focal adhesion. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AIF1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AIF1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AIF1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:130,834,623–130,835,640 | 261.3 kb | Distal (>10kb) Multiome | 715 | |
| chr9:130,940,926–130,941,385 | 155.3 kb | Distal (>10kb) Multiome | 359 | |
| chr9:130,998,218–130,998,819 | 98.0 kb | Distal (>10kb) Multiome | 380 | |
| chr9:131,008,758–131,009,603 | 87.3 kb | Distal (>10kb) Multiome | 393 | |
| chr9:131,096,120–131,097,337 | 53 bp | At TSS Multiome | 533 | |
| chr9:131,125,092–131,126,077 | 29.0 kb | Distal (>10kb) Multiome | 873 | |
| chr9:131,177,994–131,178,580 | 81.9 kb | Distal (>10kb) Multiome | 304 | |
| chr9:131,276,571–131,278,332 | 181.6 kb | Distal (>10kb) Multiome | 558 | |
| chr9:131,282,624–131,283,561 | 186.5 kb | Distal (>10kb) Multiome | 217 | |
| chr9:131,330,816–131,331,776 | 234.8 kb | Distal (>10kb) Multiome | 463 | |
| chr9:131,349,882–131,350,535 | 253.7 kb | Distal (>10kb) Multiome | 525 | |
| chr9:131,373,092–131,374,082 | 277.0 kb | Distal (>10kb) Multiome | 962 | |
| chr9:131,393,060–131,394,879 | 297.4 kb | Distal (>10kb) Multiome | 722 |
Genomic view of the AIF1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.