The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for AHRR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AHRR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AHRR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:52,897–54,263 | 268.0 kb | Distal (>10kb) Multiome | 379 | |
| chr5:91,673–92,358 | 229.6 kb | Distal (>10kb) Multiome | 279 | |
| chr5:188,610–189,107 | 132.9 kb | Distal (>10kb) Multiome | 472 | |
| chr5:217,613–219,286 | 103.5 kb | Distal (>10kb) Multiome | 692 | |
| chr5:271,018–272,107 | 50.2 kb | Distal (>10kb) Multiome | 866 | |
| chr5:317,182–317,436 | 4.3 kb | Proximal (<10kb) | 376 | |
| chr5:320,742–322,619 | 122 bp | At TSS Multiome | 441 | |
| chr5:472,056–474,135 | 151.4 kb | Distal (>10kb) Multiome | 964 | |
| chr5:523,794–524,758 | 202.5 kb | Distal (>10kb) Multiome | 106 | |
| chr5:611,543–612,836 | 290.5 kb | Distal (>10kb) Multiome | 508 |
Genomic view of the AHRR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.