The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for AHCYL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AHCYL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AHCYL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:128,937,568–128,938,346 | 287.1 kb | Distal (>10kb) Multiome | 392 | |
| chr7:129,054,212–129,055,537 | 170.0 kb | Distal (>10kb) Multiome | 1049 | |
| chr7:129,144,393–129,145,068 | 80.3 kb | Distal (>10kb) Multiome | 477 | |
| chr7:129,168,405–129,170,130 | 55.8 kb | Distal (>10kb) Multiome | 302 | |
| chr7:129,188,088–129,189,694 | 36.4 kb | Distal (>10kb) Multiome | 603 | |
| chr7:129,218,605–129,218,866 | 6.2 kb | Proximal (<10kb) | 341 | |
| chr7:129,224,228–129,225,767 | 181 bp | At TSS Multiome | 899 | |
| chr7:129,433,659–129,435,261 | 209.3 kb | Distal (>10kb) Multiome | 770 | |
| chr7:129,453,732–129,454,848 | 229.3 kb | Distal (>10kb) Multiome | 197 | |
| chr7:129,502,098–129,503,287 | 277.4 kb | Distal (>10kb) Multiome | 480 | |
| chr7:129,824,642–129,826,481 | 600.2 kb | Distal (>10kb) Multiome HiCAR | 809 | |
| chr7:129,829,901–129,830,704 | 605.2 kb | Distal (>10kb) Multiome HiCAR | 440 |
Genomic view of the AHCYL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.