The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for AHCYL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AHCYL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AHCYL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:109,548,385–109,549,096 | 436.1 kb | Distal (>10kb) Multiome HiCAR | 855 | |
| chr1:109,643,342–109,643,856 | 341.2 kb | Distal (>10kb) Multiome HiCAR | 470 | |
| chr1:109,655,698–109,656,566 | 328.6 kb | Distal (>10kb) Multiome HiCAR | 707 | |
| chr1:109,739,695–109,740,873 | 244.5 kb | Distal (>10kb) Multiome | 633 | |
| chr1:109,877,325–109,877,790 | 107.3 kb | Distal (>10kb) Multiome | 378 | |
| chr1:109,910,465–109,911,472 | 73.9 kb | Distal (>10kb) Multiome | 618 | |
| chr1:109,931,127–109,931,638 | 53.4 kb | Distal (>10kb) Multiome | 379 | |
| chr1:109,959,723–109,960,843 | 24.3 kb | Distal (>10kb) Multiome | 464 | |
| chr1:109,980,730–109,980,917 | 3.8 kb | Proximal (<10kb) | 173 | |
| chr1:109,984,134–109,985,352 | 58 bp | At TSS Multiome | 946 | |
| chr1:110,003,773–110,004,806 | 19.5 kb | Distal (>10kb) Multiome | 517 | |
| chr1:110,034,238–110,035,409 | 50.0 kb | Distal (>10kb) Multiome | 824 | |
| chr1:110,067,875–110,068,495 | 83.4 kb | Distal (>10kb) Multiome | 113 | |
| chr1:110,068,868–110,070,694 | 85.9 kb | Distal (>10kb) Multiome | 149 | |
| chr1:110,106,008–110,106,637 | 121.5 kb | Distal (>10kb) Multiome | 311 | |
| chr1:110,134,868–110,135,830 | 150.7 kb | Distal (>10kb) Multiome | 133 | |
| chr1:110,150,271–110,151,323 | 165.9 kb | Distal (>10kb) Multiome | 278 | |
| chr1:110,209,629–110,212,414 | 225.4 kb | Distal (>10kb) Multiome | 639 |
Genomic view of the AHCYL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.