Predicted to enable DNA binding activity. Involved in nuclear pore complex assembly and regulation of cytokinesis. Located in chromosome; nuclear body; and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AHCTF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AHCTF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AHCTF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:246,723,808–246,725,073 | 207.6 kb | Distal (>10kb) Multiome | 777 | |
| chr1:246,753,796–246,754,434 | 177.8 kb | Distal (>10kb) Multiome | 194 | |
| chr1:246,931,032–246,932,682 | 115 bp | At TSS Multiome | 1007 | |
| chr1:247,007,420–247,008,623 | 76.1 kb | Distal (>10kb) Multiome | 629 | |
| chr1:247,078,252–247,079,771 | 146.8 kb | Distal (>10kb) Multiome | 817 | |
| chr1:247,089,108–247,090,336 | 157.8 kb | Distal (>10kb) Multiome | 197 | |
| chr1:247,103,830–247,105,264 | 172.4 kb | Distal (>10kb) Multiome | 878 | |
| chr1:247,110,957–247,112,601 | 180.2 kb | Distal (>10kb) Multiome | 790 | |
| chr1:247,118,927–247,119,515 | 187.2 kb | Distal (>10kb) Multiome | 252 | |
| chr1:247,210,163–247,211,257 | 278.9 kb | Distal (>10kb) Multiome | 764 | |
| chr1:248,872,599–248,874,733 | 1942.0 kb | Distal (>10kb) Multiome HiCAR | 1099 |
Genomic view of the AHCTF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.