Predicted to enable GTPase activator activity and GTPase activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AGAP6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGAP6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGAP6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:49,689,972–49,690,461 | 291.9 kb | Distal (>10kb) Multiome | 90 | |
| chr10:49,761,560–49,762,540 | 219.9 kb | Distal (>10kb) Multiome | 910 | |
| chr10:49,767,863–49,769,213 | 213.5 kb | Distal (>10kb) Multiome | 132 | |
| chr10:49,941,526–49,942,344 | 40.2 kb | Distal (>10kb) Multiome | 478 | |
| chr10:50,067,797–50,068,365 | 85.8 kb | Distal (>10kb) Multiome | 393 |
Genomic view of the AGAP6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.