Predicted to enable GTPase activator activity and GTPase activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AGAP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGAP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGAP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:45,594,255–45,595,274 | 259.1 kb | Distal (>10kb) Multiome | 982 | |
| chr10:45,672,004–45,673,546 | 181.1 kb | Distal (>10kb) Multiome | 871 | |
| chr10:45,726,765–45,727,627 | 126.7 kb | Distal (>10kb) Multiome | 520 | |
| chr10:46,023,121–46,023,829 | 169.6 kb | Distal (>10kb) Multiome | 900 | |
| chr10:46,030,064–46,031,227 | 176.7 kb | Distal (>10kb) Multiome | 853 | |
| chr10:46,047,885–46,048,755 | 194.4 kb | Distal (>10kb) Multiome | 277 | |
| chr10:46,052,126–46,053,175 | 198.7 kb | Distal (>10kb) Multiome | 517 | |
| chr10:46,106,177–46,107,298 | 252.8 kb | Distal (>10kb) Multiome | 610 |
Genomic view of the AGAP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.