This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for ADPRS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADPRS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADPRS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:35,807,537–35,808,824 | 280.8 kb | Distal (>10kb) Multiome | 575 | |
| chr1:35,882,591–35,884,430 | 205.8 kb | Distal (>10kb) Multiome | 802 | |
| chr1:35,885,650–35,886,507 | 202.7 kb | Distal (>10kb) Multiome | 156 | |
| chr1:35,930,610–35,931,886 | 157.9 kb | Distal (>10kb) Multiome | 903 | |
| chr1:36,083,788–36,084,510 | 4.7 kb | Proximal (<10kb) Multiome | 194 | |
| chr1:36,088,326–36,089,393 | 23 bp | At TSS Multiome | 1023 | |
| chr1:36,148,864–36,150,075 | 60.6 kb | Distal (>10kb) Multiome | 925 | |
| chr1:36,150,344–36,151,320 | 62.1 kb | Distal (>10kb) Multiome | 524 | |
| chr1:36,155,033–36,157,490 | 67.1 kb | Distal (>10kb) Multiome | 790 | |
| chr1:36,166,478–36,167,190 | 77.9 kb | Distal (>10kb) Multiome | 85 | |
| chr1:36,176,148–36,176,823 | 87.6 kb | Distal (>10kb) Multiome | 141 | |
| chr1:36,178,119–36,179,461 | 90.1 kb | Distal (>10kb) Multiome | 222 | |
| chr1:36,187,827–36,188,464 | 99.3 kb | Distal (>10kb) Multiome | 572 | |
| chr1:36,223,459–36,225,047 | 135.4 kb | Distal (>10kb) Multiome | 1017 | |
| chr1:36,305,654–36,307,599 | 218.1 kb | Distal (>10kb) Multiome | 826 | |
| chr1:36,320,781–36,321,934 | 232.5 kb | Distal (>10kb) Multiome | 522 | |
| chr1:36,322,032–36,324,527 | 234.9 kb | Distal (>10kb) Multiome | 699 | |
| chr1:36,384,603–36,387,142 | 297.2 kb | Distal (>10kb) Multiome | 1050 | |
| chr1:36,387,290–36,388,127 | 298.9 kb | Distal (>10kb) Multiome | 280 |
Genomic view of the ADPRS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.