This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for ADI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:1,742,682–1,745,219 | 1775.0 kb | Distal (>10kb) Multiome HiCAR | 477 | |
| chr2:1,817,239–1,818,101 | 1701.8 kb | Distal (>10kb) Multiome HiCAR | 375 | |
| chr2:3,265,176–3,267,080 | 253.4 kb | Distal (>10kb) Multiome | 214 | |
| chr2:3,302,656–3,304,274 | 215.9 kb | Distal (>10kb) Multiome | 611 | |
| chr2:3,377,329–3,378,629 | 141.6 kb | Distal (>10kb) Multiome | 975 | |
| chr2:3,379,318–3,380,419 | 139.8 kb | Distal (>10kb) Multiome | 1029 | |
| chr2:3,482,920–3,483,746 | 36.1 kb | Distal (>10kb) Multiome | 137 | |
| chr2:3,518,104–3,520,209 | 284 bp | At TSS Multiome | 1083 | |
| chr2:3,557,826–3,559,338 | 38.9 kb | Distal (>10kb) Multiome | 1106 | |
| chr2:3,574,766–3,576,282 | 55.7 kb | Distal (>10kb) Multiome | 1145 | |
| chr2:3,650,709–3,651,305 | 131.7 kb | Distal (>10kb) Multiome | 403 | |
| chr2:3,651,453–3,652,406 | 132.6 kb | Distal (>10kb) Multiome | 610 | |
| chr2:3,702,909–3,704,344 | 184.0 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the ADI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.