Predicted to enable G protein-coupled receptor activity. Involved in canonical Wnt signaling pathway. Located in intracellular membrane-bounded organelle and plasma membrane. Part of Wnt signalosome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ADGRA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADGRA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADGRA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:37,675,185–37,675,906 | 121.4 kb | Distal (>10kb) Multiome | 507 | |
| chr8:37,694,827–37,698,811 | 98.4 kb | Distal (>10kb) Multiome | 830 | |
| chr8:37,735,982–37,737,291 | 60.4 kb | Distal (>10kb) Multiome | 958 | |
| chr8:37,762,144–37,763,270 | 34.3 kb | Distal (>10kb) Multiome | 889 | |
| chr8:37,794,958–37,795,334 | 1.5 kb | Proximal (<10kb) | 63 | |
| chr8:37,796,327–37,797,580 | 76 bp | At TSS Multiome | 485 | |
| chr8:37,797,835–37,798,469 | 953 bp | At TSS | 155 | |
| chr8:37,798,583–37,799,097 | 1.7 kb | Proximal (<10kb) | 236 | |
| chr8:37,801,462–37,802,090 | 5.0 kb | Proximal (<10kb) Multiome | 164 | |
| chr8:37,821,399–37,822,221 | 25.0 kb | Distal (>10kb) Multiome | 284 | |
| chr8:37,826,056–37,826,968 | 29.8 kb | Distal (>10kb) Multiome | 259 | |
| chr8:37,849,554–37,850,089 | 53.0 kb | Distal (>10kb) Multiome | 929 | |
| chr8:37,898,759–37,900,024 | 102.7 kb | Distal (>10kb) Multiome | 956 | |
| chr8:37,915,980–37,916,519 | 119.4 kb | Distal (>10kb) Multiome | 465 | |
| chr8:37,965,216–37,966,371 | 168.7 kb | Distal (>10kb) Multiome | 177 | |
| chr8:38,029,913–38,031,249 | 233.6 kb | Distal (>10kb) Multiome | 948 | |
| chr8:38,066,984–38,067,582 | 270.3 kb | Distal (>10kb) Multiome | 414 |
Genomic view of the ADGRA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.