ADCY9
adenylate cyclase 9 | AC9

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

Developmental clusters: GC1
Biological processes 29 terms
adenylate cyclase activity (GO:0004016)adenylate cyclase activity (GO:0004016)adenylate cyclase activity (GO:0004016)adenylate cyclase activity (GO:0004016)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)adenylate cyclase-activating adrenergic receptor signaling pathway (GO:0071880)axon (GO:0030424)cAMP biosynthetic process (GO:0006171)cAMP biosynthetic process (GO:0006171)cAMP biosynthetic process (GO:0006171)cellular response to glucagon stimulus (GO:0071377)cyclic nucleotide biosynthetic process (GO:0009190)dendrite (GO:0030425)intracellular signal transduction (GO:0035556)membrane (GO:0016020)membrane (GO:0016020)phosphorus-oxygen lyase activity (GO:0016849)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)renal water homeostasis (GO:0003091)signal transduction (GO:0007165)system process (GO:0003008)vascular endothelial cell response to laminar fluid shear stress (GO:0097700)vascular endothelial cell response to laminar fluid shear stress (GO:0097700)
Expression (TPM)
ADCY9 — as a Regulated Gene

TFs regulating ADCY9 0 TFs

Transcription factors with Perturb-seq knockdown data for ADCY9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCY9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ADCY9

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCY9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:3,879,373–3,881,582 235.6 kb Distal (>10kb) Multiome 727
chr16:3,938,955–3,939,490 177.2 kb Distal (>10kb) Multiome 436
chr16:4,115,028–4,117,244 102 bp At TSS Multiome 659
chr16:4,183,149–4,184,737 67.5 kb Distal (>10kb) Multiome 944
chr16:4,244,460–4,244,980 128.2 kb Distal (>10kb) Multiome 290
chr16:4,253,312–4,254,436 137.5 kb Distal (>10kb) Multiome 960
chr16:4,263,483–4,264,402 147.4 kb Distal (>10kb) Multiome 258
chr16:4,271,070–4,274,312 157.6 kb Distal (>10kb) Multiome 1130
chr16:4,293,681–4,294,322 177.6 kb Distal (>10kb) Multiome 385
chr16:4,307,236–4,308,275 191.4 kb Distal (>10kb) Multiome 635
chr16:4,309,629–4,310,195 193.5 kb Distal (>10kb) Multiome 351
chr16:4,315,041–4,316,747 199.4 kb Distal (>10kb) Multiome 520
chr16:4,327,446–4,328,634 211.8 kb Distal (>10kb) Multiome 495
chr16:4,350,579–4,351,773 234.9 kb Distal (>10kb) Multiome 674
chr16:4,371,473–4,372,791 255.4 kb Distal (>10kb) Multiome 617
chr16:4,402,485–4,403,104 286.3 kb Distal (>10kb) Multiome 450
chr16:4,415,818–4,417,201 300.3 kb Distal (>10kb) Multiome 681

Genome Browser

Genomic view of the ADCY9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:3,869,373 – 4,427,201
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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