Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADCY8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCY8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCY8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:131,032,445–131,032,888 | 7.4 kb | Proximal (<10kb) | 148 | |
| chr8:131,037,003–131,037,203 | 3.1 kb | Proximal (<10kb) | 154 | |
| chr8:131,038,908–131,042,700 | 1.3 kb | Proximal (<10kb) Multiome | 425 | |
| chr8:131,148,475–131,150,255 | 108.9 kb | Distal (>10kb) Multiome | 124 | |
| chr8:131,307,815–131,308,810 | 267.5 kb | Distal (>10kb) Multiome | 196 | |
| chr8:131,309,248–131,310,724 | 269.3 kb | Distal (>10kb) Multiome HiCAR | 175 | |
| chr8:131,312,327–131,313,567 | 272.1 kb | Distal (>10kb) Multiome HiCAR | 145 | |
| chr8:131,903,446–131,905,160 | 863.2 kb | Distal (>10kb) Multiome HiCAR | 780 |
Genomic view of the ADCY8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.