Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in regulation of ubiquinone biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ADCK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:140,397,976–140,398,715 | 275.3 kb | Distal (>10kb) Multiome | 696 | |
| chr7:140,403,831–140,404,498 | 269.7 kb | Distal (>10kb) Multiome | 333 | |
| chr7:140,478,495–140,480,078 | 194.3 kb | Distal (>10kb) Multiome | 869 | |
| chr7:140,481,148–140,482,022 | 192.2 kb | Distal (>10kb) Multiome | 15 | |
| chr7:140,488,120–140,488,789 | 185.3 kb | Distal (>10kb) Multiome | 230 | |
| chr7:140,517,960–140,518,418 | 155.7 kb | Distal (>10kb) Multiome | 472 | |
| chr7:140,639,882–140,641,732 | 33.0 kb | Distal (>10kb) Multiome | 486 | |
| chr7:140,672,673–140,674,052 | 846 bp | At TSS Multiome | 648 | |
| chr7:140,675,355–140,675,520 | 2.4 kb | Proximal (<10kb) | 193 | |
| chr7:140,696,318–140,697,705 | 23.0 kb | Distal (>10kb) Multiome | 1002 | |
| chr7:140,924,039–140,925,334 | 251.1 kb | Distal (>10kb) Multiome | 930 | |
| chr7:141,014,405–141,015,593 | 341.2 kb | Distal (>10kb) Multiome HiCAR | 1023 |
Genomic view of the ADCK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.