This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADARB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADARB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADARB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:44,801,527–44,802,290 | 272.0 kb | Distal (>10kb) Multiome | 818 | |
| chr21:44,817,098–44,818,998 | 256.0 kb | Distal (>10kb) Multiome | 775 | |
| chr21:44,845,753–44,846,245 | 227.8 kb | Distal (>10kb) Multiome | 504 | |
| chr21:44,872,991–44,875,251 | 200.1 kb | Distal (>10kb) Multiome | 841 | |
| chr21:44,939,797–44,940,292 | 133.9 kb | Distal (>10kb) Multiome | 1041 | |
| chr21:45,073,773–45,075,747 | 656 bp | At TSS Multiome | 883 | |
| chr21:45,286,648–45,288,846 | 214.2 kb | Distal (>10kb) Multiome | 708 | |
| chr21:45,292,336–45,292,948 | 218.8 kb | Distal (>10kb) Multiome | 599 |
Genomic view of the ADARB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.