This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for ADAMTS6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:65,033,655–65,036,380 | 446.3 kb | Distal (>10kb) Multiome HiCAR | 966 | |
| chr5:65,102,224–65,103,650 | 378.7 kb | Distal (>10kb) Multiome HiCAR | 507 | |
| chr5:65,480,269–65,480,789 | 1.1 kb | Proximal (<10kb) | 346 | |
| chr5:65,481,460–65,482,620 | 44 bp | At TSS Multiome | 583 | |
| chr5:65,482,735–65,483,287 | 815 bp | At TSS | 336 | |
| chr5:65,483,828–65,483,995 | 1.9 kb | Proximal (<10kb) | 131 | |
| chr5:65,562,647–65,563,667 | 81.3 kb | Distal (>10kb) Multiome | 818 | |
| chr5:65,623,893–65,625,295 | 142.6 kb | Distal (>10kb) Multiome | 910 | |
| chr5:65,721,358–65,723,398 | 240.2 kb | Distal (>10kb) Multiome | 848 |
Genomic view of the ADAMTS6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.