This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for ADAMTS18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:77,190,160–77,191,630 | 244.2 kb | Distal (>10kb) Multiome | 915 | |
| chr16:77,211,464–77,213,653 | 222.7 kb | Distal (>10kb) Multiome | 644 | |
| chr16:77,236,023–77,236,607 | 198.8 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr16:77,271,511–77,272,289 | 163.2 kb | Distal (>10kb) Multiome | 111 | |
| chr16:77,372,736–77,373,414 | 62.1 kb | Distal (>10kb) Multiome | 34 | |
| chr16:77,434,220–77,435,703 | 32 bp | At TSS Multiome | 315 | |
| chr16:77,438,635–77,439,833 | 4.2 kb | Proximal (<10kb) Multiome | 183 | |
| chr16:77,467,613–77,468,318 | 33.0 kb | Distal (>10kb) Multiome | 134 | |
| chr16:77,722,015–77,723,280 | 287.4 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the ADAMTS18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.