This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for ADAMTS13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:133,144,161–133,144,920 | 277.4 kb | Distal (>10kb) Multiome | 776 | |
| chr9:133,147,412–133,149,938 | 272.6 kb | Distal (>10kb) Multiome | 979 | |
| chr9:133,163,575–133,164,128 | 258.1 kb | Distal (>10kb) Multiome | 308 | |
| chr9:133,238,117–133,239,420 | 183.3 kb | Distal (>10kb) Multiome | 620 | |
| chr9:133,335,737–133,336,702 | 85.8 kb | Distal (>10kb) Multiome | 1038 | |
| chr9:133,347,434–133,348,830 | 73.8 kb | Distal (>10kb) Multiome | 893 | |
| chr9:133,356,029–133,357,223 | 65.4 kb | Distal (>10kb) Multiome | 648 | |
| chr9:133,375,394–133,376,740 | 45.8 kb | Distal (>10kb) Multiome | 834 | |
| chr9:133,417,747–133,418,516 | 3.9 kb | Proximal (<10kb) Multiome | 1015 | |
| chr9:133,428,444–133,429,113 | 6.7 kb | Proximal (<10kb) Multiome | 255 | |
| chr9:133,429,621–133,430,196 | 7.9 kb | Proximal (<10kb) Multiome | 197 | |
| chr9:133,458,883–133,460,984 | 37.9 kb | Distal (>10kb) Multiome | 835 | |
| chr9:133,478,485–133,479,696 | 57.2 kb | Distal (>10kb) Multiome | 653 | |
| chr9:133,534,455–133,535,168 | 112.7 kb | Distal (>10kb) Multiome | 295 | |
| chr9:133,608,924–133,609,730 | 187.4 kb | Distal (>10kb) Multiome | 411 | |
| chr9:133,738,059–133,738,688 | 316.3 kb | Distal (>10kb) Multiome | 451 |
Genomic view of the ADAMTS13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.