This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADAMTS10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:8,307,739–8,308,717 | 284.0 kb | Distal (>10kb) Multiome | 973 | |
| chr19:8,320,824–8,321,811 | 270.8 kb | Distal (>10kb) Multiome | 871 | |
| chr19:8,334,500–8,335,843 | 256.9 kb | Distal (>10kb) Multiome | 384 | |
| chr19:8,342,762–8,343,678 | 248.9 kb | Distal (>10kb) Multiome | 440 | |
| chr19:8,363,586–8,364,765 | 228.1 kb | Distal (>10kb) Multiome | 549 | |
| chr19:8,389,684–8,391,548 | 201.4 kb | Distal (>10kb) Multiome | 878 | |
| chr19:8,412,769–8,413,775 | 179.0 kb | Distal (>10kb) Multiome | 566 | |
| chr19:8,444,605–8,445,806 | 147.3 kb | Distal (>10kb) Multiome | 910 | |
| chr19:8,505,742–8,506,861 | 85.9 kb | Distal (>10kb) Multiome | 739 | |
| chr19:8,511,414–8,512,588 | 80.0 kb | Distal (>10kb) Multiome | 263 | |
| chr19:8,513,025–8,514,530 | 78.2 kb | Distal (>10kb) Multiome | 825 | |
| chr19:8,525,196–8,527,085 | 66.5 kb | Distal (>10kb) Multiome | 783 | |
| chr19:8,580,484–8,581,056 | 11.3 kb | Distal (>10kb) Multiome | 535 | |
| chr19:8,586,013–8,586,248 | 6.0 kb | Proximal (<10kb) | 232 | |
| chr19:8,591,781–8,593,224 | 274 bp | At TSS Multiome | 389 | |
| chr19:8,609,061–8,609,913 | 17.3 kb | Distal (>10kb) Multiome | 432 | |
| chr19:8,610,265–8,610,915 | 18.6 kb | Distal (>10kb) Multiome | 393 | |
| chr19:8,832,015–8,833,117 | 240.6 kb | Distal (>10kb) Multiome | 694 |
Genomic view of the ADAMTS10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.