Predicted to enable decanoate-CoA ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ACSM4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACSM4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACSM4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:7,018,028–7,019,126 | 285.4 kb | Distal (>10kb) Multiome | 824 | |
| chr12:7,108,059–7,109,582 | 194.8 kb | Distal (>10kb) Multiome | 818 | |
| chr12:7,129,788–7,131,412 | 173.8 kb | Distal (>10kb) Multiome | 619 | |
| chr12:7,188,394–7,190,508 | 115.5 kb | Distal (>10kb) Multiome | 769 | |
| chr12:7,304,557–7,305,187 | 485 bp | At TSS | 45 | |
| chr12:7,439,804–7,440,461 | 136.1 kb | Distal (>10kb) Multiome | 361 |
Genomic view of the ACSM4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.