The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Transcription factors with Perturb-seq knockdown data for ACSL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACSL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACSL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:184,536,785–184,538,298 | 270.9 kb | Distal (>10kb) Multiome | 704 | |
| chr4:184,625,573–184,626,654 | 182.6 kb | Distal (>10kb) Multiome | 388 | |
| chr4:184,648,062–184,650,476 | 159.0 kb | Distal (>10kb) Multiome | 822 | |
| chr4:184,733,143–184,734,876 | 74.3 kb | Distal (>10kb) Multiome | 1145 | |
| chr4:184,808,519–184,808,930 | 2.8 kb | Proximal (<10kb) | 116 | |
| chr4:184,812,907–184,813,506 | 7.2 kb | Proximal (<10kb) | 505 | |
| chr4:184,814,706–184,816,098 | 9.0 kb | Proximal (<10kb) | 552 | |
| chr4:184,825,249–184,826,846 | 17.5 kb | Distal (>10kb) Multiome | 644 | |
| chr4:184,983,798–184,984,312 | 175.5 kb | Distal (>10kb) Multiome | 307 | |
| chr4:185,004,689–185,005,528 | 196.6 kb | Distal (>10kb) Multiome | 348 | |
| chr4:185,018,062–185,018,650 | 210.0 kb | Distal (>10kb) Multiome | 181 |
Genomic view of the ACSL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.