The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
Transcription factors with Perturb-seq knockdown data for ACP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:47,160,949–47,161,864 | 87.3 kb | Distal (>10kb) Multiome | 322 | |
| chr11:47,176,472–47,177,856 | 71.8 kb | Distal (>10kb) Multiome | 857 | |
| chr11:47,184,866–47,187,095 | 62.3 kb | Distal (>10kb) Multiome | 849 | |
| chr11:47,214,114–47,215,529 | 33.9 kb | Distal (>10kb) Multiome | 785 | |
| chr11:47,248,482–47,249,399 | 114 bp | At TSS Multiome | 1059 | |
| chr11:47,257,299–47,258,204 | 9.0 kb | Proximal (<10kb) Multiome | 519 | |
| chr11:47,259,310–47,259,960 | 10.8 kb | Distal (>10kb) Multiome | 270 | |
| chr11:47,268,988–47,270,613 | 21.0 kb | Distal (>10kb) Multiome | 884 | |
| chr11:47,354,896–47,355,720 | 106.6 kb | Distal (>10kb) Multiome | 670 | |
| chr11:47,399,791–47,400,763 | 151.5 kb | Distal (>10kb) Multiome | 450 | |
| chr11:47,407,671–47,409,059 | 159.6 kb | Distal (>10kb) Multiome | 986 | |
| chr11:47,425,998–47,427,263 | 177.7 kb | Distal (>10kb) Multiome | 879 | |
| chr11:47,508,005–47,509,036 | 259.7 kb | Distal (>10kb) Multiome | 73 |
Genomic view of the ACP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.