Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to be located in peroxisomal matrix. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ACOXL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACOXL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACOXL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:110,677,731–110,678,843 | 54.4 kb | Distal (>10kb) Multiome HiCAR | 773 | |
| chr2:110,687,491–110,688,343 | 44.7 kb | Distal (>10kb) Multiome | 174 | |
| chr2:110,688,515–110,689,481 | 43.7 kb | Distal (>10kb) Multiome | 229 | |
| chr2:110,729,250–110,729,392 | 3.1 kb | Proximal (<10kb) | 19 | |
| chr2:110,732,052–110,733,412 | 78 bp | At TSS Multiome | 341 | |
| chr2:110,735,569–110,735,970 | 3.0 kb | Proximal (<10kb) | 64 | |
| chr2:110,770,133–110,771,424 | 38.3 kb | Distal (>10kb) Multiome | 297 |
Genomic view of the ACOXL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.