This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for ACOT11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACOT11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACOT11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:54,405,024–54,410,267 | 132.8 kb | Distal (>10kb) Multiome | 991 | |
| chr1:54,411,735–54,412,248 | 130.3 kb | Distal (>10kb) Multiome | 104 | |
| chr1:54,474,500–54,475,180 | 67.3 kb | Distal (>10kb) Multiome | 231 | |
| chr1:54,487,606–54,488,753 | 53.9 kb | Distal (>10kb) Multiome | 766 | |
| chr1:54,488,856–54,491,244 | 52.7 kb | Distal (>10kb) Multiome | 749 | |
| chr1:54,541,930–54,543,207 | 183 bp | At TSS Multiome | 769 | |
| chr1:54,548,049–54,548,280 | 5.8 kb | Proximal (<10kb) | 170 | |
| chr1:54,715,256–54,716,151 | 173.5 kb | Distal (>10kb) Multiome | 918 | |
| chr1:54,764,040–54,765,112 | 222.4 kb | Distal (>10kb) Multiome | 791 | |
| chr1:54,775,004–54,775,454 | 233.0 kb | Distal (>10kb) Multiome | 135 | |
| chr1:54,781,116–54,781,700 | 239.1 kb | Distal (>10kb) Multiome | 190 | |
| chr1:54,800,637–54,801,431 | 258.9 kb | Distal (>10kb) Multiome | 286 |
Genomic view of the ACOT11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.