This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for ACBD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACBD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACBD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:27,015,228–27,016,107 | 226.5 kb | Distal (>10kb) Multiome | 15 | |
| chr10:27,099,907–27,101,042 | 141.7 kb | Distal (>10kb) Multiome | 756 | |
| chr10:27,153,856–27,156,360 | 86.8 kb | Distal (>10kb) Multiome | 970 | |
| chr10:27,240,222–27,241,262 | 1.5 kb | Proximal (<10kb) Multiome | 831 | |
| chr10:27,241,284–27,242,441 | 14 bp | At TSS Multiome | 851 | |
| chr10:27,242,763–27,243,117 | 2.2 kb | Proximal (<10kb) | 512 | |
| chr10:27,252,226–27,253,021 | 10.5 kb | Distal (>10kb) Multiome | 405 | |
| chr10:27,258,839–27,259,511 | 17.0 kb | Distal (>10kb) Multiome | 220 | |
| chr10:27,319,712–27,320,433 | 77.9 kb | Distal (>10kb) Multiome | 239 | |
| chr10:27,460,714–27,461,433 | 218.9 kb | Distal (>10kb) Multiome | 40 | |
| chr10:27,465,047–27,465,926 | 223.4 kb | Distal (>10kb) Multiome | 128 | |
| chr10:27,503,674–27,504,967 | 262.1 kb | Distal (>10kb) Multiome | 901 |
Genomic view of the ACBD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.