Predicted to enable GTPase activator activity and zinc ion binding activity. Predicted to act upstream of or within neuron migration and regulation of neuron projection development. Predicted to be located in endosome membrane and growth cone. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ACAP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACAP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACAP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,019,142–1,021,414 | 290.0 kb | Distal (>10kb) Multiome | 707 | |
| chr1:1,032,438–1,034,753 | 276.4 kb | Distal (>10kb) Multiome | 475 | |
| chr1:1,040,071–1,041,597 | 268.6 kb | Distal (>10kb) Multiome | 410 | |
| chr1:1,058,856–1,060,114 | 250.0 kb | Distal (>10kb) Multiome | 609 | |
| chr1:1,068,556–1,069,991 | 240.4 kb | Distal (>10kb) Multiome | 577 | |
| chr1:1,079,478–1,080,558 | 229.5 kb | Distal (>10kb) Multiome | 746 | |
| chr1:1,115,769–1,117,022 | 193.4 kb | Distal (>10kb) Multiome | 743 | |
| chr1:1,157,424–1,158,362 | 152.0 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,231,448–1,233,390 | 77.5 kb | Distal (>10kb) Multiome | 884 | |
| chr1:1,273,333–1,274,645 | 35.6 kb | Distal (>10kb) Multiome | 779 | |
| chr1:1,293,434–1,294,454 | 15.7 kb | Distal (>10kb) Multiome | 234 | |
| chr1:1,304,741–1,305,201 | 4.4 kb | Proximal (<10kb) | 469 | |
| chr1:1,305,632–1,305,871 | 3.7 kb | Proximal (<10kb) | 385 | |
| chr1:1,307,375–1,310,219 | 1.3 kb | Proximal (<10kb) Multiome | 897 | |
| chr1:1,324,278–1,325,394 | 15.2 kb | Distal (>10kb) Multiome | 735 | |
| chr1:1,348,716–1,350,027 | 39.9 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr1:1,353,403–1,354,425 | 44.3 kb | Distal (>10kb) Multiome | 276 | |
| chr1:1,374,767–1,375,798 | 65.8 kb | Distal (>10kb) Multiome | 1113 | |
| chr1:1,398,861–1,399,955 | 89.9 kb | Distal (>10kb) Multiome | 879 | |
| chr1:1,406,992–1,407,823 | 97.7 kb | Distal (>10kb) Multiome | 938 | |
| chr1:1,435,318–1,436,066 | 126.1 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,511,442–1,512,404 | 202.4 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 231.0 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 265.2 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,945–1,600,642 | 290.5 kb | Distal (>10kb) Multiome | 307 |
Genomic view of the ACAP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.