Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022]
Transcription factors with Perturb-seq knockdown data for ACACB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACACB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACACB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:108,856,753–108,858,260 | 297.0 kb | Distal (>10kb) Multiome | 698 | |
| chr12:109,052,237–109,053,072 | 102.1 kb | Distal (>10kb) Multiome | 965 | |
| chr12:109,069,700–109,070,229 | 84.7 kb | Distal (>10kb) Multiome | 118 | |
| chr12:109,093,224–109,093,868 | 61.1 kb | Distal (>10kb) Multiome | 998 | |
| chr12:109,097,190–109,098,740 | 56.6 kb | Distal (>10kb) Multiome | 758 | |
| chr12:109,110,997–109,111,481 | 43.5 kb | Distal (>10kb) Multiome | 593 | |
| chr12:109,154,096–109,155,355 | 187 bp | At TSS Multiome | 595 | |
| chr12:109,308,986–109,310,221 | 154.6 kb | Distal (>10kb) Multiome | 331 |
Genomic view of the ACACB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.