This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for ABRAXAS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABRAXAS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABRAXAS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:83,283,973–83,285,305 | 200.4 kb | Distal (>10kb) Multiome | 879 | |
| chr4:83,334,415–83,335,295 | 150.2 kb | Distal (>10kb) Multiome | 455 | |
| chr4:83,455,343–83,456,320 | 29.2 kb | Distal (>10kb) Multiome | 983 | |
| chr4:83,484,511–83,485,585 | 32 bp | At TSS Multiome | 905 | |
| chr4:83,490,998–83,491,136 | 5.9 kb | Proximal (<10kb) | 79 | |
| chr4:83,535,410–83,536,979 | 51.2 kb | Distal (>10kb) Multiome | 690 | |
| chr4:83,589,080–83,590,013 | 104.4 kb | Distal (>10kb) Multiome | 157 |
Genomic view of the ABRAXAS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.