This gene encodes a LIM zinc-binding domain-containing protein that binds to actin filaments and mediates interactions between actin and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2017]
Transcription factors with Perturb-seq knockdown data for ABLIM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABLIM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABLIM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:114,239,111–114,240,320 | 287.3 kb | Distal (>10kb) Multiome | 417 | |
| chr10:114,303,821–114,305,401 | 222.1 kb | Distal (>10kb) Multiome | 424 | |
| chr10:114,402,845–114,405,341 | 122.3 kb | Distal (>10kb) Multiome | 410 | |
| chr10:114,441,939–114,442,669 | 84.6 kb | Distal (>10kb) Multiome | 90 | |
| chr10:114,471,249–114,473,211 | 54.4 kb | Distal (>10kb) Multiome | 486 | |
| chr10:114,522,639–114,522,928 | 4.0 kb | Proximal (<10kb) | 31 | |
| chr10:114,526,358–114,527,267 | 31 bp | At TSS Multiome | 770 | |
| chr10:114,767,677–114,768,866 | 241.1 kb | Distal (>10kb) Multiome | 416 | |
| chr10:114,821,343–114,822,880 | 294.9 kb | Distal (>10kb) Multiome | 639 |
Genomic view of the ABLIM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.