This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for ABI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:26,566,682–26,567,578 | 293.8 kb | Distal (>10kb) Multiome | 219 | |
| chr10:26,697,102–26,698,223 | 163.3 kb | Distal (>10kb) Multiome | 822 | |
| chr10:26,860,047–26,861,781 | 93 bp | At TSS Multiome | 923 | |
| chr10:26,923,645–26,924,112 | 62.9 kb | Distal (>10kb) Multiome | 66 | |
| chr10:27,015,228–27,016,107 | 154.7 kb | Distal (>10kb) Multiome | 15 | |
| chr10:27,099,907–27,101,042 | 239.4 kb | Distal (>10kb) Multiome | 756 | |
| chr10:27,153,856–27,156,360 | 294.4 kb | Distal (>10kb) Multiome | 970 |
Genomic view of the ABI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.