ABHD8

abhydrolase domain containing 8 | FLJ11743, MGC14280, MGC2512

This gene is upstream of, and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34. The predicted protein contains alpha/beta hydrolase fold and secretory lipase domains. [provided by RefSeq, Jul 2008]

Developmental clusters: GC6

Biological processes 12 terms

carboxylic ester hydrolase activity (GO:0052689)catalytic activity (GO:0003824)cytoplasm (GO:0005737)cytoplasm (GO:0005737)extracellular exosome (GO:0070062)glycerophospholipase activity (GO:0004620)lipid homeostasis (GO:0055088)lysophosphatidic acid acyltransferase activity (GO:0042171)negative regulation of NLRP3 inflammasome complex assembly (GO:1900226)negative regulation of NLRP3 inflammasome complex assembly (GO:1900226)phosphatidic acid biosynthetic process (GO:0006654)protein binding (GO:0005515)

Expression (TPM)

TFs regulating ABHD8 0 TFs

Transcription factors with Perturb-seq knockdown data for ABHD8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ABHD8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:17,074,934–17,076,532	227.8 kb	Distal (>10kb) Multiome	890
chr19:17,209,430–17,210,427	93.6 kb	Distal (>10kb) Multiome	245
chr19:17,215,005–17,215,979	87.9 kb	Distal (>10kb) Multiome	897
chr19:17,225,705–17,226,889	77.0 kb	Distal (>10kb) Multiome	870
chr19:17,234,748–17,236,650	67.5 kb	Distal (>10kb) Multiome	612
chr19:17,244,882–17,247,104	57.3 kb	Distal (>10kb) Multiome	862
chr19:17,247,935–17,248,860	54.8 kb	Distal (>10kb) Multiome	588
chr19:17,266,931–17,267,755	36.2 kb	Distal (>10kb) Multiome	720
chr19:17,281,537–17,283,120	20.6 kb	Distal (>10kb) Multiome	669
chr19:17,292,242–17,293,049	10.7 kb	Distal (>10kb) Multiome	513
chr19:17,294,076–17,294,320	9.1 kb	Proximal (<10kb)	192
chr19:17,302,721–17,303,771	33 bp	At TSS Multiome	636
chr19:17,305,286–17,306,514	2.3 kb	Proximal (<10kb) Multiome	947
chr19:17,309,159–17,310,151	6.1 kb	Proximal (<10kb) Multiome	741
chr19:17,327,532–17,329,548	24.6 kb	Distal (>10kb) Multiome	370
chr19:17,334,287–17,335,052	31.4 kb	Distal (>10kb) Multiome	870
chr19:17,336,574–17,338,240	34.0 kb	Distal (>10kb) Multiome	924
chr19:17,340,311–17,341,226	37.2 kb	Distal (>10kb) Multiome	419
chr19:17,390,414–17,391,521	87.8 kb	Distal (>10kb) Multiome	615
chr19:17,394,998–17,395,433	91.8 kb	Distal (>10kb) Multiome	403
chr19:17,398,863–17,399,537	95.8 kb	Distal (>10kb) Multiome	132
chr19:17,403,087–17,404,355	100.1 kb	Distal (>10kb) Multiome	211
chr19:17,419,503–17,420,821	116.5 kb	Distal (>10kb) Multiome	869
chr19:17,424,865–17,425,411	121.7 kb	Distal (>10kb) Multiome	328
chr19:17,448,174–17,448,841	145.2 kb	Distal (>10kb) Multiome	392
chr19:17,468,858–17,470,905	166.7 kb	Distal (>10kb) Multiome	743
chr19:17,488,739–17,489,689	185.7 kb	Distal (>10kb) Multiome	381
chr19:17,511,113–17,512,592	208.1 kb	Distal (>10kb) Multiome	1021
chr19:17,538,878–17,540,353	236.4 kb	Distal (>10kb) Multiome	725
chr19:17,555,194–17,556,523	252.1 kb	Distal (>10kb) Multiome	713
chr19:17,576,463–17,577,455	273.6 kb	Distal (>10kb) Multiome	236
chr19:17,579,580–17,580,242	276.6 kb	Distal (>10kb) Multiome	281

Genome Browser

Genomic view of the ABHD8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.