Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Predicted to be located in dendritic spine; postsynaptic density membrane; and recycling endosome membrane. Predicted to be active in endosome membrane; glutamatergic synapse; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ABHD17C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD17C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD17C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:80,403,712–80,405,109 | 291.1 kb | Distal (>10kb) Multiome | 379 | |
| chr15:80,503,942–80,504,568 | 190.9 kb | Distal (>10kb) Multiome | 13 | |
| chr15:80,694,769–80,696,059 | 32 bp | At TSS Multiome | 455 | |
| chr15:80,778,964–80,780,209 | 83.9 kb | Distal (>10kb) Multiome | 528 | |
| chr15:80,780,345–80,780,949 | 85.4 kb | Distal (>10kb) Multiome | 676 | |
| chr15:80,989,298–80,990,315 | 294.6 kb | Distal (>10kb) Multiome | 780 |
Genomic view of the ABHD17C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.