Enables palmitoyl-(protein) hydrolase activity. Involved in negative regulation of NLRP3 inflammasome complex assembly; protein depalmitoylation; and protein localization to membrane. Located in endosome membrane; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ABHD17A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD17A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD17A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:1,592,085–1,593,444 | 292.7 kb | Distal (>10kb) Multiome | 883 | |
| chr19:1,604,859–1,606,501 | 279.8 kb | Distal (>10kb) Multiome | 902 | |
| chr19:1,651,519–1,653,514 | 232.5 kb | Distal (>10kb) Multiome | 909 | |
| chr19:1,725,307–1,726,101 | 159.7 kb | Distal (>10kb) Multiome | 455 | |
| chr19:1,811,638–1,813,347 | 72.9 kb | Distal (>10kb) Multiome | 782 | |
| chr19:1,826,853–1,827,379 | 58.3 kb | Distal (>10kb) Multiome | 193 | |
| chr19:1,848,048–1,848,953 | 36.8 kb | Distal (>10kb) Multiome | 819 | |
| chr19:1,851,701–1,852,216 | 33.5 kb | Distal (>10kb) Multiome | 115 | |
| chr19:1,855,082–1,856,620 | 30.0 kb | Distal (>10kb) Multiome | 476 | |
| chr19:1,861,439–1,865,723 | 21.5 kb | Distal (>10kb) Multiome | 891 | |
| chr19:1,875,645–1,876,693 | 9.3 kb | Proximal (<10kb) Multiome | 887 | |
| chr19:1,877,235–1,877,541 | 8.0 kb | Proximal (<10kb) | 7 | |
| chr19:1,885,058–1,885,861 | 33 bp | At TSS Multiome | 495 | |
| chr19:1,904,556–1,906,084 | 20.0 kb | Distal (>10kb) Multiome | 907 | |
| chr19:1,940,240–1,942,987 | 55.5 kb | Distal (>10kb) Multiome | 901 | |
| chr19:2,034,637–2,035,967 | 149.6 kb | Distal (>10kb) Multiome | 368 | |
| chr19:2,041,744–2,042,811 | 156.7 kb | Distal (>10kb) Multiome | 586 | |
| chr19:2,049,171–2,052,365 | 165.8 kb | Distal (>10kb) Multiome | 977 | |
| chr19:2,060,703–2,062,560 | 176.1 kb | Distal (>10kb) Multiome | 913 | |
| chr19:2,095,898–2,097,954 | 211.2 kb | Distal (>10kb) Multiome | 945 | |
| chr19:2,150,726–2,152,200 | 266.2 kb | Distal (>10kb) Multiome | 761 | |
| chr19:2,163,561–2,164,587 | 278.4 kb | Distal (>10kb) Multiome | 750 |
Genomic view of the ABHD17A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.