Predicted to enable hydrolase activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ABHD14A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD14A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD14A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:51,681,945–51,682,394 | 292.8 kb | Distal (>10kb) Multiome | 291 | |
| chr3:51,706,614–51,707,579 | 268.1 kb | Distal (>10kb) Multiome HiCAR | 506 | |
| chr3:51,798,234–51,798,899 | 176.4 kb | Distal (>10kb) Multiome | 120 | |
| chr3:51,800,441–51,801,024 | 174.5 kb | Distal (>10kb) Multiome | 20 | |
| chr3:51,801,591–51,802,872 | 172.7 kb | Distal (>10kb) Multiome | 223 | |
| chr3:51,868,646–51,869,606 | 106.0 kb | Distal (>10kb) Multiome | 50 | |
| chr3:51,941,340–51,942,909 | 33.0 kb | Distal (>10kb) Multiome HiCAR | 890 | |
| chr3:51,955,723–51,956,827 | 18.5 kb | Distal (>10kb) Multiome | 289 | |
| chr3:51,967,071–51,968,598 | 7.5 kb | Proximal (<10kb) Multiome | 581 | |
| chr3:51,973,571–51,975,404 | 1.1 kb | Proximal (<10kb) Multiome | 886 | |
| chr3:51,982,506–51,983,633 | 8.2 kb | Proximal (<10kb) Multiome | 933 | |
| chr3:51,990,597–51,991,772 | 15.9 kb | Distal (>10kb) Multiome | 145 | |
| chr3:51,995,468–51,996,121 | 20.9 kb | Distal (>10kb) Multiome | 938 | |
| chr3:52,001,516–52,001,992 | 26.6 kb | Distal (>10kb) Multiome | 448 | |
| chr3:52,055,881–52,058,048 | 82.4 kb | Distal (>10kb) Multiome | 937 | |
| chr3:52,128,194–52,128,700 | 153.3 kb | Distal (>10kb) Multiome | 376 | |
| chr3:52,153,766–52,155,196 | 179.6 kb | Distal (>10kb) Multiome | 896 | |
| chr3:52,197,554–52,198,856 | 223.0 kb | Distal (>10kb) Multiome | 731 | |
| chr3:52,238,767–52,239,716 | 264.2 kb | Distal (>10kb) Multiome | 763 | |
| chr3:52,245,446–52,246,450 | 270.9 kb | Distal (>10kb) Multiome | 553 |
Genomic view of the ABHD14A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.