The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ABCF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,325,606–30,327,611 | 244.5 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:30,344,843–30,345,715 | 226.2 kb | Distal (>10kb) Multiome | 892 | |
| chr6:30,357,696–30,358,238 | 213.6 kb | Distal (>10kb) Multiome | 207 | |
| chr6:30,466,230–30,466,713 | 104.9 kb | Distal (>10kb) Multiome | 369 | |
| chr6:30,489,117–30,490,512 | 81.1 kb | Distal (>10kb) Multiome HiCAR | 750 | |
| chr6:30,516,006–30,516,707 | 55.1 kb | Distal (>10kb) Multiome | 739 | |
| chr6:30,555,407–30,557,765 | 14.8 kb | Distal (>10kb) Multiome | 1161 | |
| chr6:30,570,822–30,571,949 | 28 bp | At TSS Multiome | 1000 | |
| chr6:30,614,393–30,615,939 | 43.8 kb | Distal (>10kb) Multiome | 837 | |
| chr6:30,616,770–30,618,155 | 46.1 kb | Distal (>10kb) Multiome | 1072 | |
| chr6:30,626,560–30,627,206 | 55.4 kb | Distal (>10kb) Multiome | 802 | |
| chr6:30,646,505–30,648,035 | 75.9 kb | Distal (>10kb) Multiome | 961 | |
| chr6:30,672,571–30,673,266 | 101.5 kb | Distal (>10kb) Multiome | 812 | |
| chr6:30,679,032–30,679,479 | 107.7 kb | Distal (>10kb) Multiome | 603 | |
| chr6:30,686,268–30,688,032 | 115.8 kb | Distal (>10kb) Multiome | 801 | |
| chr6:30,690,445–30,691,240 | 119.5 kb | Distal (>10kb) Multiome | 644 | |
| chr6:30,716,986–30,717,874 | 146.0 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:30,719,428–30,720,577 | 148.7 kb | Distal (>10kb) Multiome | 724 | |
| chr6:30,721,307–30,722,103 | 150.1 kb | Distal (>10kb) Multiome | 872 | |
| chr6:30,725,731–30,726,564 | 154.8 kb | Distal (>10kb) Multiome | 478 | |
| chr6:30,740,996–30,745,094 | 171.3 kb | Distal (>10kb) Multiome | 1233 | |
| chr6:30,763,647–30,765,193 | 193.0 kb | Distal (>10kb) Multiome | 850 |
Genomic view of the ABCF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.