The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ABCD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:153,469,901–153,471,108 | 254.1 kb | Distal (>10kb) Multiome | 508 | |
| chrX:153,598,511–153,599,722 | 125.6 kb | Distal (>10kb) Multiome | 459 | |
| chrX:153,609,905–153,610,354 | 114.8 kb | Distal (>10kb) Multiome | 404 | |
| chrX:153,687,144–153,688,247 | 37.1 kb | Distal (>10kb) Multiome | 201 | |
| chrX:153,723,829–153,725,285 | 245 bp | At TSS Multiome | 620 | |
| chrX:153,726,395–153,727,168 | 2.1 kb | Proximal (<10kb) Multiome | 529 | |
| chrX:153,793,808–153,795,045 | 69.6 kb | Distal (>10kb) Multiome | 733 | |
| chrX:153,875,415–153,875,856 | 150.8 kb | Distal (>10kb) Multiome | 847 | |
| chrX:153,878,887–153,879,684 | 154.4 kb | Distal (>10kb) Multiome | 235 | |
| chrX:153,927,955–153,928,728 | 203.6 kb | Distal (>10kb) Multiome | 711 | |
| chrX:153,934,763–153,935,658 | 210.3 kb | Distal (>10kb) Multiome | 446 |
Genomic view of the ABCD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.