The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for ABCC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:95,113,495–95,114,435 | 187.4 kb | Distal (>10kb) Multiome | 109 | |
| chr13:95,296,633–95,296,858 | 4.6 kb | Proximal (<10kb) | 200 | |
| chr13:95,300,582–95,302,240 | 176 bp | At TSS Multiome | 751 | |
| chr13:95,359,817–95,361,148 | 59.0 kb | Distal (>10kb) Multiome | 216 | |
| chr13:95,403,573–95,404,765 | 102.7 kb | Distal (>10kb) Multiome | 412 | |
| chr13:95,552,034–95,553,905 | 251.2 kb | Distal (>10kb) Multiome | 283 |
Genomic view of the ABCC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.